Prevention & lipidsMeta-analysis
Sex differences in treatment of familial hypercholesterolaemia: a meta-analysis
- Systematic review and meta-analysis
Authors' conclusion
Females with FH were less likely to be treated intensively and to reach guideline-recommended LDL-C targets.
Study context
- Population
- Adults with familial hypercholesterolaemia (FH)133 publications
- Comparison
- Females vs males with FH
- Outcome
- Sex-related disparities in treatment, response and LDL-C target achievement
Pooled result
As reported in the abstract
OR
- on lipid-lowering therapy; 25 observational studies, 129 441 participants
- .74 (95% CI .66-.85)
- reaching LDL-C < 2.5 mmol/L
- .85 (95% CI .74-.97)
Further pooled results
Response to fixed doses of lipid-lowering therapy (16 interventional trials, 1840 participants)
- No differences between males and females in response
MACE incl. MI, atherosclerotic CVD and CV mortality
- Male sex associated with two-fold greater relative risk
Original publication
Sex differences in treatment of familial hypercholesterolaemia: a meta-analysis. Eur Heart J. Published 8 July 2024. doi:10.1093/eurheartj/ehae417
Summarised from the published abstract; every number is checked against it