Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study
Authors' conclusion
The rate of cognitive decline did not differ significantly between males and females. However, the impact of several vascular risk factors on cognitive decline was greater in females than in males.
Study context
- Population
- UK Biobank participants >55 years of age
- Participants
- 19,067 participants
- Exposure
- Females vs males
- Outcome
- Cognitive decline (executive function, processing speed, memory) and association with vascular risk factors by sex
- Follow-up
- Between 2014 and 2019
Methodological detailsUK Biobank, repeated measures mixed-effect model
- UK Biobank
- Repeated measures mixed-effect model
Main finding
As reported in the abstract
Cognitive decline by sex · 5-year period
- Significant sex-by-time interaction in matrix pattern completion
- P = 0.03
- Sex-by-time interaction reduced after adjusting for vascular risk factors
- P = 0.08
- High LDL, low education and high BP had greater effect on rate of executive function decline in females vs males (sex∗vascular risk factor interaction)
- P < 0.05
Observational data: associations, not effects.
Further findings
Baseline cognitive scores (2014)
- Females had lower scores in all 3 domains
Original publication
Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study. JACC Adv. Published 8 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →