Valvular & structural heart disease
Sex-Related Differences in Clinical Characteristics and Outcome Prediction Among Patients Undergoing Transcatheter Tricuspid Valve Intervention
Authors' conclusion
Even though men and women differ in the etiology of TR, both sexes show similar survival rates after TTVI. The TAPSE/mPAP ratio can improve prognostication after TTVI
Study context
- Population
- Patients with severe tricuspid regurgitation undergoing transcatheter tricuspid valve intervention (TTVI)
- Participants
- 702 patients
- Exposure
- Women vs men
- Womenn = 386
- Menn = 316reference
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
2-year survival after TTVI
P = 0.144
Observational data: associations, not effects.
Further findings
CAD
P = 5.6 × 10-6
Secondary ventricular TR etiology
P = 1.4 × 10-4
Secondary atrial TR etiology
P = 2.0 × 10-6
2-year mortality by sex-specific tricuspid annulus plane systolic excursion (TAPSE)/mean pulmonary artery pressure (mPAP) threshold (subgroup)
| HR | P value | |
|---|---|---|
| Women with TAPSE/mPAP <0.612 mm/mm Hg3.43-fold increased HR | 3.43 | P < 0.001 |
| Men with TAPSE/mPAP <0.434 mm/mm Hg2.05-fold increased HR | 2.05 | P = 0.001 |
Independent predictors of 2-year mortality (multivariate regression)
- NYHA class, TAPSE and mPAP independent predictors; prognostic significance of TAPSE and mPAP differed between sexes
Original publication
Sex-Related Differences in Clinical Characteristics and Outcome Prediction Among Patients Undergoing Transcatheter Tricuspid Valve Intervention. JACC Cardiovasc Interv. Published 5 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →