Valvular & structural heart disease
Sex-related differences in prosthesis-patient mismatch after surgical aortic valve replacement and long-term outcomes
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.30 95% CI 1.20–1.40Authors' conclusion
Sex-specific EOAi thresholds associated with outcomes emerged in this large regional study.
Study context
- Population
- Patients undergoing surgical aortic valve replacement (AVR) at a Québec institute, 2000–2021
- Participants
- 7,319 patients
- Exposure
- Prosthesis-patient mismatch (PPM) vs no PPM after surgical AVR, by sex
- Outcome
- Long-term all-cause mortality
- Follow-up
- Median 12.6 years
Methodological detailssingle-centre, prospective follow-up
- Single-centre
- Prospective follow-up
Main finding
All-cause mortality
Hazard ratio
1.30
95% CI 1.20–1.40
P < 0.0001
PPMvs No PPM
HR 1.30 (95% CI 1.20–1.40); P < 0.0001
As reported in the abstract
- After multivariable adjustment, VARC-3 PPM independently associated with outcome only in women
- P ≤ 0.04
- With sex-specific spline-derived EOAi thresholds, PPM independently associated with outcome in both sexes
- P ≤ 0.04
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV mortality · median follow-up 12.6 yearsPPMvs No PPMWhole cohort; no interaction between sexes (P ≥ .74) | 1.39 (1.23–1.57) | P < 0.0001 | |
| 0.512Hazard ratio (log scale) |
Any-degree PPM prevalence (VARC-3) · any-degree PPM; severe PPM also P < .0001
P < 0.0001
Severe PPM
Cardiovascular (CV) mortality · median follow-up 12.6 years
- 1238 (16.9%) CV deaths
Original publication
Sex-related differences in prosthesis-patient mismatch after surgical aortic valve replacement and long-term outcomes. Eur Heart J. Published 18 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →