Arrhythmias & electrophysiology
Sex-Related Differences in Ventricular Tachyarrhythmia Events in Patients With Implantable Cardioverter-Defibrillator and Prior Ventricular Tachyarrhythmias
Authors' conclusion
Women with a history of prior VT/VF experienced a lower risk recurrent VT/VF requiring ICD therapy when compared to men. Black Women had a risk similar to men, whereas the lower risk for VT/VF in women was observed primarily in White women.
Study context
- Population
- Patients with implantable cardioverter-defibrillator (ICD) (secondary or primary prevention indication) who experienced ventricular tachycardia (VT)/ventricular fibrillation (VF) before enrolment in the RAID trial
- Participants
- 714 patients
- Comparison
- Women vs men
- Womenn = 124
- Menn = 590reference
- Primary endpoint
- First and recurrent VT/VF requiring antitachycardia pacing or ICD shock, and death
- Follow-up
- Mean 26.81 ± 14.52 months
Primary result
As reported in the abstract
VT/VF/death; VT/VF; VT/VF treated with ATP; VT/VF treated with ICD shock
- VT/VF/death
- HR 0.67; P = 0.029
- VT/VF
- HR 0.68; P = 0.049
- VT/VF treated with antitachycardia pacing
- HR 0.59; P = 0.019
- VT/VF treated with ICD shock
- HR 0.54; P = 0.035
Further findings
VT rate
P = 0.002
Shock-requiring VT/VF rate
P = 0.30
| Outcome | HR | P value |
|---|---|---|
| Recurrent VT/VF | 0.35 | P < 0.001 |
| VT/VF, by race (subgroup) — White women vs White men | 0.36 | P < 0.001 |
| VT/VF, by race (subgroup) — Black women vs Black men | 1.06 | P = 0.851 |
- VT/VF, by race (subgroup): interaction P = 0.013
Death
- HR for death (women vs men) similar to the other endpoints, not significant
- HR: 0.61; P = 0.162
Original publication
Sex-Related Differences in Ventricular Tachyarrhythmia Events in Patients With Implantable Cardioverter-Defibrillator and Prior Ventricular Tachyarrhythmias. JACC Clin Electrophysiol. Published 29 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it