Arrhythmias & electrophysiology
Temporal Changes in LGE-CMR Enhancement After Monopolar Biphasic Focal Pulsed Field Ablation for Pulmonary Vein Isolation
Authors' conclusion
Serial LGE-CMR demonstrated substantial enhancement reduction of acute lesions following focal point-by-point PFA for PVI, which remained largely confined to the PV antra and adjacent posterior wall, providing novel in-human insights into lesion maturation following focal PFA delivery.
Study context
- Population
- Patients with symptomatic paroxysmal or persistent atrial fibrillation (AF) undergoing index pulsed field ablation (PFA)-guided pulmonary vein isolation (PVI) using the CENTAURI system with a focal point-by-point lesion delivery strategy
- Participants
- Six consecutive patients
- Comparison
- Changes in enhancement burden and left atrial (LA) dimensions were analyzed between imaging timepoints.
Methodological detailsLGE-CMR 1 day and 90±10 days after ablation
- LGE-CMR 1 day and 90±10 days after ablation
Main finding
As reported in the abstract
Baseline characteristics
Mean age
65±7 years
Paroxysmal AF
five patients (83%)
Further findings
| Outcome | Acute imaging | Chronic imaging | P value |
|---|---|---|---|
| Enhancement within the right pulmonary vein (PV) region · decreased | 3.3±2.2% | 0.8±0.8% | P = 0.030 |
| Proportion of enhanced tissue (right PV region) · decreased | 24.1±13.5% | 5.7±5.8% | P = 0.017 |
| Enhancement around the left PVs | 4.4±3.1% | 1.4±1.2% | P = 0.064 |
| Posterior wall enhancement · decreased | 2.4±1.1% | 0.3±0.3% | P = 0.007 |
| Global LA enhancement · decreased | 12.8±6.2% | 3.3±1.6% | P = 0.013 |
Acute PVI
- Acute PVI was achieved in all patients without procedural complications
LA volume
- LA volume remained unchanged
Original publication
Temporal Changes in LGE-CMR Enhancement After Monopolar Biphasic Focal Pulsed Field Ablation for Pulmonary Vein Isolation. Heart Rhythm. Published 19 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it