Valvular & structural heart disease
Sex-specific aortic valve calcifications in patients undergoing transcatheter aortic valve implantation
Authors' conclusion
AVC is a strong predictor for moderate PVL post-TAVI. Although the AVC load in men is higher compared to women, there is no difference in the incidence of moderate PVL. Sex-specific Agatston score cut-offs to predict moderate PVL were almost double as high in men vs. women.
Study context
- Population
- Patients undergoing TAVI with a Sapien3 or Evolut valve54% male
- Participants
- 1,801 patients
- Exposure
- Men vs women
- Outcome
- Sex-specific differences in amount and distribution of aortic valve calcification (AVC) (multidetector computed tomography (MDCT)) and correlation of AVC load with PVL post-TAVI
Methodological detailstwo tertiary care institutions
- Two tertiary care institutions
Main finding
As reported in the abstract
Agatston score
Men
2567
IQR 1657–3913
Women
1615
IQR 905–2484
P < 0.01
Observational data: associations, not effects.
Further findings
Moderate PVL post-TAVI · no difference
P = 0.63
Annulus area
P < 0.01
| Outcome | Men | Women |
|---|---|---|
| Agatston score cut-off predicting moderate PVL (ROC) | 4070 | 2341 |
| Sensitivity | 0.73 | 0.74 |
| Specificity | 0.79 | 0.73 |
- Moderate paravalvular leakage (PVL) post-TAVI: Overall: 1104 (61%) none-trace, 648 (36%) mild, 49 (3%) moderate PVL
Original publication
Sex-specific aortic valve calcifications in patients undergoing transcatheter aortic valve implantation. Eur Heart J Cardiovasc Imaging. Published 21 January 2023. doi:10.
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