Heart failure & cardiomyopathies
Too Little of a Good Thing: Strong Associations Between Cardiac Size and Fitness Among Women
Authors' conclusion
A small ventricle is strongly associated with low CRF because of the combined effect of a smaller resting stroke volume and an attenuated capacity to increase with exercise.
Study context
- Population
- Healthy women aged >30 years (51 ± 9 years)
- Participants
- 185 women
- Exposure
- Quartiles of resting left ventricular end-diastolic volume (LVEDV)
- Outcome
- Association between cardiorespiratory fitness (CRF) (Vo2peak) and ventricular size and function (cardiac magnetic resonance (CMR), echocardiography)
Main finding
As reported in the abstract
- Vo2peak strongly associated with resting LVEDV and RV end-diastolic volume (R2 = 0.58-0.63)
- P < 0.0001
- Vo2peak weakly associated with resting left ventricular (LV) systolic and diastolic function (R2 = 0.01-0.06)
- P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | Q1 | Q4 |
|---|---|---|
| Cardiac reserve during exercise by resting LVEDV quartile | ||
| Change in LV end-systolic volume | −4 mL | −12 mL |
| Change in LV stroke volume | +11 mL | +20 mL |
| Change in cardiac output | +6.6 L/min | +10.3 L/min |
- Cardiac reserve during exercise by resting LVEDV quartile: interaction P < 0.001 for all
Cardiac reserve during exercise by resting LVEDV quartile
- Increasing LVEDV quartiles positively associated with cardiac reserve
Original publication
Too Little of a Good Thing: Strong Associations Between Cardiac Size and Fitness Among Women. JACC Cardiovasc Imaging. Published 8 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →