Arrhythmias & electrophysiology
Spatial ventricular gradient is associated with pacing-induced cardiomyopathy
Authors' conclusion
Assessment of the SVG both before and immediately after pacemaker implantation can help identify patients at elevated risk of PICM
Study context
- Population
- Patients with pacemakers implanted 2003–2012 at the Hospital of the University of Pennsylvania
- Participants
- 203 patients
- Exposure
- Higher vs lower tertiles of mean adjusted spatial ventricular gradient (SVG) azimuth
- Outcome
- Pacing-induced cardiomyopathy (PICM)
- Follow-up
- Over
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PICM
Adjusted hazard ratio
1.95
P = 0.047
SVG azimuth before pacemaker implantation
Adjusted hazard ratio
2.55
P = 0.003
SVG azimuth immediately after pacemaker implantation
Observational data: associations, not effects.
Further findings
Pacing-induced cardiomyopathy (PICM) incidence during follow-up
- Developed PICM
- 44 (22%)
Unadjusted predictors of PICM
- Male sex, native QRS duration (without bundle branch block), and native and paced mean adjusted SVG azimuth predicted future PICM in unadjusted Cox regression
Original publication
Spatial ventricular gradient is associated with pacing-induced cardiomyopathy. Heart Rhythm. Published 28 December 2024. doi:10.
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