Valvular & structural heart disease
Stressed Blood Volume in Severe Tricuspid Regurgitation: Implications for Transcatheter Treatment
Authors' conclusion
In patients with severe TR, eSBV is associated with obesity, renal and liver dysfunction, more severe heart failure, attenuated reduction of venous congestion after TEER, and adverse clinical outcomes.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) undergoing right heart catheterization prior to tricuspid transcatheter edge-to-edge repair (TEER)
- Participants
- 279 patients
- Exposure
- Higher vs lower estimated stressed blood volume
- Outcome
- Associations of eSBV
Main finding
As reported in the abstract
Estimated stressed blood volume (eSBV) associated with obesity, renal and hepatic dysfunction and cardiac remodeling
P < 0.05 for all
eSBV correlated with pulmonary artery and cardiac filling pressures and RV-pulmonary artery coupling
P < 0.05 for all
After TEER, eSBV > median: less reduction in right atrial pressures, peripheral edema and ascites vs lower eSBV
P < 0.05 for all
Higher eSBV independent predictor of death and HF hospitalization
P < 0.05 for all
Observational data: associations, not effects.
Original publication
Summarised from the published abstract; every number is checked against it