Valvular & structural heart disease
Stroke volume index and transvalvular flow rate trajectories in severe aortic stenosis treated with transcatheter aortic valve replacement (TAVR)
Authors' conclusion
Baseline flow status was not an independent predictor of mid-term mortality among all-comers with severe AS undergoing TAVR. Flow recovery early after TAVR was frequent. Post-TAVR FR, but not SVi, was independently associated with mid-term all-cause mortality.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing TAVR731 with post-TAVR assessment
- Participants
- 980 patients
- Exposure
- Low vs normal flow before and after TAVR
- Outcome
- All-cause mortality
- Follow-up
- Up to 3 years
Main finding
As reported in the abstract
All-cause mortality up to 3 years (multivariable Cox)
Hazard ratio (95% CI)
SVibaseline flow status (SVi <35 mL/m²); not an independent predictor
1.22(0.85–1.82)
FRbaseline flow status (FR <200 mL/s); not an independent predictor
0.78(0.48–1.27)
Reduced FR following TAVRpost-TAVR; independent predictor
1.67(1.02–2.74)
SVipost-TAVR; not an independent predictor
0.97(0.53–1.78)
Observational data: associations, not effects.
Further findings
| Outcome | Reduced FR | P value |
|---|---|---|
| 3-year estimated mortality by FR trajectory · up to 3 yearsRecovered FR vs Reduced FR | 37.7% | P = 0.003 |
| 3-year estimated mortality by FR trajectory · up to 3 yearsRecovered FR vs Normal baseline FR · similar | P = 0.317 |
- 3-year estimated mortality by flow rate (FR) trajectory: Recovered FR 13.3%
Flow recovery after TAVR (baseline low flow) · early (5 days, IQR 2-29) post-TAVR
- Stroke volume index (SVi) recovered
- 40.1%
- FR recovered
- 49.0%
Original publication
Stroke volume index and transvalvular flow rate trajectories in severe aortic stenosis treated with TAVR. Eur Heart J Cardiovasc Imaging. Published 8 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →