Study of heart function in PRE-Eclampsia during and after PreGnancy (SHePREG): The pilot cohort
Authors' conclusion
Postpartum recovery of heart function after severe PreE is attenuated in women with deleterious cardiomyopathic genetic polymorphisms.
Study context
- Population
- Pregnant women (32 ± 4 years) with or without severe pre-eclampsia, enrolled 2019–2021, TTE in late pregnancy and 3 months postpartum
- Exposure
- Severe PreE vs control; genetic positive vs genetic negative severe PreE
- Severe PreEn = 14
- Controln = 8reference
- Outcome
- Heart function (myocardial relaxation, mitral e') by TTE
- Follow-up
- Late pregnancy and 3 months postpartum
Methodological detailspilot
- Pilot
Main finding
As reported in the abstract
Mitral e' (myocardial relaxation) · late pregnancy
P < 0.05
- Deleterious cardiomyopathic variants in severe PreE (in-silico analysis)
- 58%
Observational data: associations, not effects.
Further findings
| Outcome | Control | G- | G+ |
|---|---|---|---|
| Mitral e', entry vs postpartum · 103 ± 33 days postpartum | |||
| Entry | 13.2 ± 2.3 | 11.0 ± 3.0 | 10.5 ± 1.7 |
| Postpartum | 13.9 ± 1.7 | 13.7 ± 2.8 | 10.8 ± 2.4 |
- Mitral e', entry vs postpartum: Control entry vs postpartum P = .464
- Mitral e', entry vs postpartum: G- entry vs postpartum P < .001 (recovery to control level)
- Mitral e', entry vs postpartum: G+ entry vs postpartum P = .853
Original publication
Study of heart function in PRE-Eclampsia during and after PreGnancy (SHePREG): The pilot cohort. Am Heart J. Published 14 December 2023. doi:10.
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