Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study
Authors' conclusion
Independent of brachial BP, a biochemical phenotype of subclinical primary aldosteronism is negatively associated with cardiovascular health, including greater arterial stiffness, adverse cardiac remodeling, and incident hypertension.
Study context
- Population
- Adults aged 40–69 years from the randomly sampled population-based CARTaGENE cohort (Québec, Canada)
- Participants
- 1,284 adults
- Exposure
- Higher vs lower aldosterone-to-renin ratio
- Outcome
- Arterial stiffness (central BP, pulse wave velocity), adverse cardiac remodeling on CMR (indexed maximum left atrial volume, LV mass index, LV remodeling index, LV hypertrophy) and incident hypertension
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Higher aldosterone-to-renin ratio associated with increased central blood pressure (BP), pulse wave velocity, indexed maximum left atrial volume, LV mass index and LV remodeling index
all P<0.05
Higher aldosterone-to-renin ratio: odds of LV hypertrophy, OR
1.32 (1.002-1.73) (95% CI)
Higher aldosterone-to-renin ratio: odds of incident hypertension, OR
1.29 (1.03-1.62) (95% CI)
Observational data: associations, not effects.
Further findings
Participants with normal BP (subgroup)
- All associations consistent in participants with normal BP
Original publication
Summarised from the published abstract; every number is checked against it