Heart failure & cardiomyopathies
Sudden cardiac death after heart transplantation: a population-based study
Authors' conclusion
HTx recipients, particularly the youngest, were at very high risk of SCD compared with the general population.
Study context
- Population
- Consecutive heart transplant (HTx) recipients, 2 centres, transplanted 2004–2016
- Participants
- 1,246 participants2 centres
- Exposure
- HTx recipients vs general population
- HTx recipientsn = 1,246
- Outcome
- Annual incidence of SCD beyond the first year post-transplant
- Follow-up
- Beyond the first year post-transplant
Methodological detailspopulation-based, 2 centres, competing risk multivariate Cox model, sudden cardiac death (SCD) centrally adjudicated
- Population-based
- 2 centres
- Competing risk multivariate Cox model
- SCD centrally adjudicated
Main finding
As reported in the abstract
Annual incidence of SCD
P < 0.001
Observational data: associations, not effects.
Further findings
SCD risk by recipient age
- Standardized mortality ratio for SCD up to, recipients ≤30 years
- 837
Cause of death beyond the first year
- SCD was the leading cause of death
Independent determinants of SCD (competing risk multivariate Cox model)
- Older donor age
- P = 0.003
- Younger recipient age
- P = 0.001
- Recipient ethnicity
- P = 0.034
- Pre-existing donor-specific antibodies
- P = 0.009
- Last LVEF
- P = 0.048
Original publication
Sudden cardiac death after heart transplantation: a population-based study. Europace. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →