Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study
Authors' conclusion
By 12 years after the Norwood operation, shunt type has minimal association with RVEF, peak Vo2, complication rates, and transplant-free survival.
Study context
- Population
- Children with hypoplastic left heart syndrome after Norwood operation (SVR trial cohort), followed through 12 years of ageof 313 transplant-free survivors
- Participants
- 237 children
- Comparison
- Right ventricle-to-pulmonary artery shunt (RVPAS) vs modified Blalock-Taussig-Thomas shunt (mBTTS) at Norwood operation
- Primary endpoint
- RV ejection fraction (right ventricular ejection fraction (RVEF)) by CMR
- Follow-up
- 10 through 14 years of age
Methodological detailslongitudinal follow-up
- Longitudinal follow-up
Primary result
As reported in the abstract
RVEF by CMR
RVPAS
51
± 9.6 · n = 90
mBTTS
52
± 7.4 · n = 75
P = 0.43
Further findings
Transplant-free survival · 12 years of age · 163 of 277 vs 144 of 267
P = 0.11
Percentage predicted peak Vo2 for age and sex
P = 0.71
Percentage predicted work rate for size and sex
P = 0.65
Safety
Cumulative incidence of protein-losing enteropathy
P = 0.04
Catheter interventions
P = 0.01
Catheter interventions
- Similar rates of other complications
Original publication
Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study. Circulation. Published 5 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it