Arrhythmias & electrophysiology
Sweetened Beverages, Genetic Susceptibility, and Incident Atrial Fibrillation: A Prospective Cohort Study
Authors' conclusion
Consumption of SSB and ASB at >2 L/wk was associated with an increased risk for AF. PJ consumption ≤1 L/wk was associated with a modestly lower risk for AF. The association between sweetened beverages and AF risk persisted after adjustment for genetic susceptibility to AF.
Study context
- Population
- Participants free of baseline AF, with genetic data and a completed 24-hour diet questionnaire9,362 incident AF cases
- Participants
- 201,856 participants
- Exposure
- Consumption of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB) or PJ vs nonconsumption
- Outcome
- Incident AF
- Follow-up
- Median 9.9 years
Main finding
As reported in the abstract
Each group vs nonconsumersHazard ratio (95% CI)
SSB >2 L/wkmultivariable-adjusted
1.10(1.01–1.20)
ASB >2 L/wkmultivariable-adjusted
1.20(1.10–1.31)
PJ ≤1 L/wk
0.92(0.87–0.97)
Observational data: associations, not effects.
Further findings
Incident AF by genetic risk (joint analysis)
| HR (95% CI) | ||
|---|---|---|
| High genetic risk, ASB >2 L/wkHighest HR | 3.51 (2.94–4.19) | |
| Low genetic risk, PJ ≤1 L/wkLowest HR | 0.77 (0.65–0.92) | |
| 0.20.5125Hazard ratio (log scale) |
- No significant interactions between SSB, ASB or PJ consumption and genetic predisposition to AF
Original publication
Sweetened Beverages, Genetic Susceptibility, and Incident Atrial Fibrillation: A Prospective Cohort Study. Circ Arrhythm Electrophysiol. Published 5 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →