Arrhythmias & electrophysiology
Evaluation of the in vivo chemical reactivity of a novel copolymer insulation on cardiac leads in a single-center study
Authors' conclusion
Because the molar mass of a polymer is directly related to its mechanical integrity, the observed decrease in molar mass of Optim likely translates into premature insulation defects and is consistent with the observed increased rate of electrical malfunction/noise in this subset of cardiac leads.
Study context
- Population
- Extracted pacing and defibrillator leads with thermoplastic outer insulation, Emory University Hospitals
- Participants
- 70 extracted leads
- Comparison
- Optim vs PEU 55D vs PEU 80A outer lead insulation
- Outcome
- Chemical reactivity of insulation: molar mass, extent of reaction [Mn(t = 0)/Mn(t)] vs implant time
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Molar mass vs implant time · 10 years of implant
- Optim molar mass decreased to 40% of initial value at 10 years
- No change in PEU molar mass resolved over same 10-year implant time
- Implant times 0.12 to 16.26 years
Original publication
Evaluation of the in vivo chemical reactivity of a novel copolymer insulation on cardiac leads in a single-center study. Heart Rhythm. Published 2 March 2024. doi:10.
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