Heart failure & cardiomyopathies
Systemic Immune-Inflammation Index as a Prognostic Marker for Advanced Chronic Heart Failure with Renal Dysfunction
Authors' conclusion
This study suggested that SII is a novel independent predictor of mortality in advanced chronic heart failure patients with renal dysfunction
Study context
- Population
- Advanced chronic HF patients with renal dysfunction, First affiliated hospital of Zhengzhou University, September 2019 to December 2020
- Participants
- 717 patients
- Exposure
- High SII vs low SII
- High-SIIn = 238
- Low-SIIn = 479reference
- Outcome
- All-cause mortality (ACM)
- Follow-up
- Within 30 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
ACM
Hazard ratio (95% CI)P value
High-SIIvs Low-SIImultivariate Cox; incidence increased by 70.3%
1.703(1.200–2.337)
P = 0.002SIIunivariate Cox
2.144(1.565–2.938)
P < 0.001- Kaplan-Meier (K-M): higher risk of all-cause mortalities (ACM) with high SII within 30 months
- log-rank P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACE (high-SII n = 203 vs low-SII n = 514; cut-off 1406)High-SIIvs Low-SIIMultivariate Cox; incidence increased by 58.3% | 1.583 (1.213–2.065) | P = 0.001 | |
| 0.512Hazard ratio (log scale) |
MACE (high-SII n = 203 vs low-SII n = 514; cut-off 1406)
| HR (95% CI) | P value | ||
|---|---|---|---|
| SIIUnivariate Cox | 1.625 (1.261–2.905) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
- MACE (high-SII n = 203 vs low-SII n = 514; cut-off 1406) — K-M: higher risk of MACE with high SII within 30 months
- log-rank P < 0.001
Original publication
Systemic Immune-Inflammation Index as a Prognostic Marker for Advanced Chronic Heart Failure with Renal Dysfunction. ESC Heart Fail. Published 31 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →