Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients
Authors' conclusion
In this cohort of pediatric Fontan patients, SV systolic function was diminished at baseline, and there was a direct correlation between 2D strain and 3D-EF with percent predicted peak VO2, and additionally, 3D-EF with endothelial function.
Study context
- Population
- Pediatric Fontan patients (ages 8–19) cleared for exercise, entering the RE-ENERGIZE FONTAN exercise intervention
- Participants
- 114 patients
- Outcome
- Single ventricle (SV) systolic function (2D/3D strain, 3D-EF) and its association with exercise capacity and endothelial function (RHI)
- Follow-up
- Baseline
Methodological detailsbaseline cohort of an ongoing randomised trial
- Baseline cohort of an ongoing randomised trial
Main finding
As reported in the abstract
- 2D-LS/global longitudinal strain (GLS) (mean ± SD)
- −15.6% ± 4.19%
- Circumferential strain (mean ± SD)
- −18.7% ± 6.83%
- 3D-EF (mean ± SD)
- 49.9% ± 7.26%
- 3D-GLS (mean ± SD)
- −16.8% ± 4.37%
- 2D-LS/GLS vs percent predicted peak VO2
- R = −0.28, P = .007
- 3D-EF vs percent predicted peak VO2
- R = 0.24, P = .019
- 3D-EF vs RHI
- R = 0.29, P = .0071
Observational data: associations, not effects.
Further findings
Exercise capacity and endothelial function · baseline
- Peak VO2 (mean ± SD)
- 1,290 ± 502 mL/min
- Percent predicted peak VO2 (mean ± SD)
- 67.8% ± 15.6%
- RHI (mean ± SD)
- 1.44 ± 0.576
Baseline characteristics
- Median age, years (IQR)
- 12.7 (10.2, 15.6)
- Median time from Fontan operation, years (IQR)
- 8.8 (6.2, 12.0)
- Single right ventricle
- 57 (50%)
Original publication
Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients. Am Heart J. Published 31 May 2025. doi:10.
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