Exercise-Induced Hypertension Is Associated With Gestational Hypertension Occurrence in Patients With Repaired Aortic Coarctation
Authors' conclusion
EIH may be an important predictor for the occurrence of GHTN in patients with rCoA.
Study context
- Population
- Patients with repaired aortic coarctation (rCoA) with normal resting blood pressure (BP) seen at a cardio-obstetrics clinic at a quaternary center between January 2011 and April 2023met inclusion criteria, of 88 patients screened
- Participants
- 32 patients
- Exposure
- Association between exercise-induced hypertension (EIH) and subsequent occurrence of gestational hypertension (GHTN)
- GHTNn = 10
- Outcome
- GHTN during pregnancy
- Follow-up
- During pregnancy
Main finding
As reported in the abstract
GHTN occurred
10 patients
31%
Of whom had pre-eclampsia (of the 10 with GHTN)
3
Observational data: associations, not effects.
Further findings
Predictors of GHTN/pre-eclampsia
- Prior miscarriages, prior hypertensive disorders of pregnancy, and EIH were associated with occurrence of GHTN/pre-eclampsia
- Body mass index and lack of aspirin use were not associated
Risk of developing GHTN (multivariable analysis)
- EIH independently associated with a 3-fold increase in the risk of developing GHTN
- Multivariable analysis
Global longitudinal strain and peak oxygen consumption
- Patients with GHTN more frequently had abnormal global longitudinal strain on echocardiogram and lower peak oxygen consumption on cardiopulmonary exercise testing
Baseline characteristics
- Average age
- 29 ± 4 years
- None had significant recurrent coarctation or more-than-mild aortic valve disease
Original publication
Exercise-Induced Hypertension Is Associated With Gestational Hypertension Occurrence in Patients With Repaired Aortic Coarctation. JACC Adv. Published 30 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it