Arrhythmias & electrophysiology
T1 Mapping for Identifying the Substrate in Patients With Apparently Idiopathic Premature Ventricular Complexes
Authors' conclusion
Increased global T1, a marker of interstitial fibrosis, was detected in patients with apparently idiopathic PVC and was significantly associated with non-LBBB inferior axis morphology and high PVC burden.
Study context
- Population
- Patients with frequent apparently idiopathic premature ventricular complexes (PVCs) who underwent cardiac magnetic resonance imaging (MRI), 2020–2021
- Participants
- 70 vs 70
- Comparison
- Patients with apparently idiopathic PVCs vs healthy controls
- Patientsn = 70
- Healthy controlsn = 70reference
- Outcome
- Myocardial fibrosis by T1 mapping (global T1 value)
Methodological detailssex- and age-matched healthy controls
- Sex- and age-matched healthy controls
Main finding
As reported in the abstract
Global T1 value
- Global T1 value significantly higher in patients than in controls
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (per 10-ms increase) | P value |
|---|---|---|
| High PVC burden (>20%/24 h), multivariate analysis | 1.22 | P = 0.02 |
- Extracellular volume (patients)
- 26.03% · ± 2.16%
Global T1 and ECV across PVC tertiles
- Stepwise increase in global T1 across PVC tertiles
- P = 0.03
- No stepwise increase in extracellular volume
- P = 0.85
Global native T1 by PVC morphology
- Higher global native T1 with non-LBBB inferior axis vs LBBB inferior axis morphology
- P = 0.005
Global T1 and PVC burden
- Correlation of global T1 with PVC burden
- r = 0.28, P = 0.02
Original publication
T1 Mapping for Identifying the Substrate in Patients With Apparently Idiopathic Premature Ventricular Complexes. JACC Clin Electrophysiol. Published 22 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →