Arrhythmias & electrophysiology
A tailored substrate-based approach using focal pulsed field catheter ablation in patients with atrial fibrillation and advanced atrial substrate: Procedural data and 6-month success rates
Authors' conclusion
Tailored substrate-based F-PFA in patients with AF and advanced atrial substrate is safe and effective. Acute procedural success was 100% with 64% freedom from arrhythmias after 6 months.
Study context
- Population
- Patients with atrial fibrillation (AF) and advanced atrial substrate treated by an focal pulsed field ablation (F-PFA) system (CardioFocus) through contact force-sensing catheters integrated in electroanatomic mapping systems
- Participants
- 83 patients
- Outcome
- Arrhythmia recurrence
- Follow-up
- 6 months
Methodological detailsprospectively enrolled
- Prospectively enrolled
Main finding
As reported in the abstract
| Group | Value | AF | Atypical AFl |
|---|---|---|---|
| F-PFA | 30 of 83 patients | 21 | 9 |
F-PFA
Value30 of 83 patients
AF21
Atypical AFl9
Observational data: associations, not effects.
Further findings
Procedures performed
Patients
- De novo pulmonary vein isolation
- 36
- Pulmonary vein reisolation
- 30
- Mitral anterior line (atypical AFl or anterior low-voltage areas)
- 19
- Posterior wall isolation (low-voltage areas or evoked delayed electrograms during premature atrial extrastimuli)
- 38
- Cavotricuspid isthmus ablation (typical AFl)
- 24
Procedural and fluoroscopy times
Minutes
- Median procedural time
- 115
- Median fluoroscopy time
- 7
Safety
- No complications occurred
Original publication
A tailored substrate-based approach using focal pulsed field catheter ablation in patients with atrial fibrillation and advanced atrial substrate: Procedural data and 6-month success rates. Heart Rhythm. Published 17 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it