Valvular & structural heart diseaseCohort study
Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation
- retrospective multicentre study
- registry
- consecutive patients
- 27 centres in Europe and North America
Authors' conclusion
Findings from the PRIME-MR registry highlight substantial reductions in residual MR severity and complication rates over time in PMR patients undergoing M-TEER.
Study context
- Population
- Patients undergoing M-TEER for primary MR (PMR)consecutive patients included in the analysis
- Participants
- 3,082 patients
- Exposure
- M-TEER procedures were categorised into four time periods (2009-2013, 2014-2016, 2017-2019, and 2020-2023), to align with major device updates
Main finding
As reported in the abstract
Procedures with complications
- Complication rates decreased over time
- P for trend < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | 2009-2013 | 2014-2016 | 2017-2019 | 2020-2023 |
|---|---|---|---|---|
| Technical efficacy (residual MR ≤1+) | 54.0% | Not reported in the abstract | Not reported in the abstract | 68.4% |
| Stable results without any deterioration · one-year follow-up | 63.6% | Not reported in the abstract | Not reported in the abstract | 74.4% |
| NYHA Class ≥III | 85.9% | Not reported in the abstract | Not reported in the abstract | 71.8% |
| Mean Society of Thoracic Surgeons score | mean 5.6% | Not reported in the abstract | Not reported in the abstract | mean 4.6% |
- Technical efficacy (residual mitral regurgitation (MR) ≤1+) — Technical efficacy increased over time
- p for trend<0.001
- Stable results without any deterioration — Increased occurrence of stable results over time
- p for trend=0.03
- Mean Society of Thoracic Surgeons score — Lower over time
- p for trend<0.0001
Baseline characteristics
- Median age, years
- 82 [interquartile range 76.0-85.0]
- Female
- 45.1%
- NYHA Class ≥III
- 80.4%
MR severity at baseline
- less severe MR
Original publication
Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation. EuroIntervention. Published 15 June 2026. doi:10.4244/eij-d-25-01308
Summarised from the published abstract; every number is checked against it