Valvular & structural heart disease
Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 2.01 95% CI 1.35–3.00Authors' conclusion
In the PRIME-MR registry, 20% of patients with primary mitral regurgitation had severe TR at baseline. TR severity improved in 30% of TR≥Sev patients after successful M-TEER. The presence of TR≥Sev was independently associated with increased all-cause mortality at 2 years.
Study context
- Population
- Patients with severe primary mitral regurgitation undergoing mitral transcatheter edge-to-edge repair (M-TEER) with successful procedures (mitral regurgitation≤Moderate)analyzed, registry included 3083 patients
- Participants
- 2,155 patients
- Exposure
- Tricuspid regurgitation (TR)≤Moderate versus TR≥Severe
- TR≥Sevn = 421
- TR≤Modn = 1,734
- Outcome
- all-cause mortality
- Follow-up
- 2 years
Methodological details25 international sites, 2008 to 2022
- 25 international sites
- 2008 to 2022
Main finding
As reported in the abstract
Adjusted hazard ratio
2.01
95% CI 1.35–3.00
P < 0.001
By group
TR≤Moderate (TR≤Mod)vs TR≥Severe (TR≥Sev)
adjusted hazard ratio 2.01 (95% CI 1.35–3.00); P < 0.001
Observational data: associations, not effects.
Further findings
Heart failure hospitalization · 2 years
| Outcome | TR≥Sev | TR≤Mod |
|---|---|---|
| Mortality, residual TR≥Sev vs TR≤Mod | — not stated in the abstract | 19.9% |
— not stated in the abstract
- Heart failure hospitalization: P Gray =0.018
- Mortality, residual TR≥Sev vs TR≤Mod: residual TR≥Sev 30.4%
- Mortality, residual TR≥Sev vs TR≤Mod: P log-rank =0.0037
Baseline characteristics, TR≥Sev vs TR≤Mod
- New York Heart Association III/IV
- P = 0.003
- Shorter 6-minute walk distance
- P < 0.001
- Higher NT-proBNP
- P < 0.001
- Higher creatinine
- P < 0.001
- Higher pulmonary artery pressures
- P < 0.001
- Atrial fibrillation
- P < 0.001
- More diuretics
- P < 0.001
TR≥Sev decreased after successful M-TEER
- TR≥Sev decreased
- 30%
Original publication
Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry. Circ Cardiovasc Interv. Published 11 September 2026. doi:10.
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