Coronary disease & ACS

The Association Between Angiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction

JACC Cardiovasc IntervPublished Nested case-control study

Main finding · Baseline maximum RWS (RWSmax)Result — go to the resultRisk ratio 7.25 95% CI 3.94–13.37

Authors' conclusion

Among angiographically mild to intermediate lesions, a high-strain pattern identified by angiography-derived RWS was associated with an increased risk of AMI events.

Study context

Population
Patients with ≥1 de novo mild to intermediate coronary lesion at prior angiography, hospitalized again for repeat angiography ≥1 month later
Participants
44 vs 132
Comparison
Lesion-related acute myocardial infarction (AMI) vs matched controls without AMI
  • AMIn = 44
  • Controlsn = 132reference
Outcome
Association between angiography-derived RWS and future AMI events
Methodological detailsmatched, retrospective cohort, 3 controls per case
  • Matched
  • Retrospective cohort
  • 3 controls per case

Main finding

Baseline maximum RWS (RWSmax)

Risk ratio

7.25

95% CI 3.94–13.37

P < 0.001

By group

RWSmax >12%
risk ratio 7.25 (95% CI 3.94–13.37); P < 0.001

As reported in the abstract

RWSmax predictive of lesion-related AMI, AUC
0.83 (95% CI: 0.76-0.90; P < 0.001)
Optimal RWSmax cutoff
>12%

Observational data: associations, not effects.

Original publication

The Association Between Angiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction. JACC Cardiovasc Interv. Published 8 May 2023. doi:10.1016/j.jcin.2023.02.012

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