Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non–Flow-Limiting Stenosis
Primary result · LOCEResult — go to the resultHazard ratio 2.70 95% CI 1.37–5.32Authors' conclusion
In diabetic patients with non-flow-limiting stenosis, RWS can help to localize stenoses with OCT-VFs. RWS predicts increased risk for LOCE, both independently from-and incrementally beyond-OCT-VFs.
Study context
- Population
- Diabetic patients with non-flow-limiting coronary stenosis
- Participants
- 366 patients · 435 lesions
- Comparison
- Radial wall strain (RWS)-positive vs RWS-negative
- RWS-positiven = 88
- RWS-negativen = 278reference
- Primary endpoint
- LOCE (cardiac death, target vessel-related MI, clinically driven target lesion revascularization)
- Follow-up
- Median 3.2 years
Methodological detailspost hoc analysis, prespecified RWS cutoff ≥13.0%
- Post hoc analysis
- Prespecified RWS cutoff ≥13.0%
Primary result
LOCE · median 3.2 years
Hazard ratio
2.70
95% CI 1.37–5.32
P = 0.004
Events by treatment group
RWS-positive vs RWS-negative
HR 2.70 (95% CI 1.37–5.32); P = 0.004
As reported in the abstract
Further findings
Maximal RWS predicting lesions with any OCT-VFs
- AUC 0.630 (95% CI 0.571-0.688)
- P < 0.001
Mediation of RWS effect on lesion-oriented composite endpoint (LOCE) by OCT-VFs
- Direct effect β 0.099 (95% CI 0.029-0.168)
- P = 0.006
- Indirect effect β 0.004 (95% CI −0.008 to 0.015)
- P = 0.555
- Mediation proportion 3.9% (95% CI −5.0% to 20.3%)
Reclassification for LOCE adding RWS to any OCT-VFs
- Positive cNRI −0.060 (95% CI −0.420 to 0.318)
- P = 0.749
- Negative cNRI 0.583 (95% CI 0.474-0.681)
- P < 0.001
- Integrated discrimination improvement 0.066 (95% CI 0.013-0.182)
- P = 0.010
Original publication
Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non–Flow-Limiting Stenosis. JACC Cardiovasc Interv. Published 10 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it