The Association Between Periodontal Disease and Cardiovascular Disease: Insights From Imaging, Observational, and Genetic Data
Authors' conclusion
Using an integrated approach across imaging, observational, and genomic data, periodontal disease is associated with biomarkers of subclinical remodeling as well as incident CAD.
Study context
- Population
- UK Biobank participants59,019 with paired cardiovascular magnetic resonance (CMR)
- Participants
- 481,915 participants
- Exposure
- Periodontal disease vs no periodontal disease
- Periodontal diseasen = 91,022
- Outcome
- CMR biomarkers of LV remodeling (LV end-diastolic volume, LVEF, LV mass, LV mass:volume ratio, LV global longitudinal strain, native T1) and incident coronary artery disease (CAD)
Methodological detailsUK Biobank, multivariable linear regression, Cox proportional hazards regression, genome-wide polygenic risk score
- UK Biobank
- Multivariable linear regression
- Cox proportional hazards regression
- Genome-wide polygenic risk score
Main finding
As reported in the abstract
Periodontal disease vs No periodontal diseaseHazard ratio (95% CI)
Incident CAD, median follow-up 13.8 years
1.09(1.07–1.13)
- Left ventricle (LV) mass:volume ratio
- effect size 0.00233 (95% CI 0.0006–0.004)
- Native T1
- effect size −0.86 ms (95% CI −1.63 to −0.09)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| CAD per SD increase in periodontal disease polygenic risk score | 1.03 (1.02–1.05) | |
| 0.512Odds ratio (log scale) |
Original publication
The Association Between Periodontal Disease and Cardiovascular Disease: Insights From Imaging, Observational, and Genetic Data. JACC Adv. Published 31 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it