Valvular & structural heart disease
The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality
Authors' conclusion
These findings suggest that symptom status, independent of AS severity, is a key risk factor for adverse outcomes. Further research is needed to assess the benefits of early intervention in these high-risk groups.
Study context
- Population
- Adults diagnosed with aortic stenosis (AS) among adults with echocardiograms from 2010 to 2019 in a large, integrated health care systemadults diagnosed with AS, of 602,821 adults with echocardiograms
- Participants
- 40,333 adults
- Exposure
- Associations between AS-related symptoms, AS severity, and clinical outcomes
- Outcome
- Potential AS-related symptoms by AS severity
Methodological detailslarge, integrated health care system, validated natural language processing algorithms, Cox models
- Large, integrated health care system
- Validated natural language processing algorithms
- Cox models
Main finding
As reported in the abstract
- Mild
- 80%
- Mild-moderate
- 77%
- Moderate
- 77%
- Moderate-severe
- 85%
- Severe
- 87%
Observational data: associations, not effects.
Further findings
| Outcome | Symptomatic moderate AS | Severe AS without symptoms |
|---|---|---|
| Death and AS-related hospitalization · median follow-up of 2.2 yearsAfter multivariable adjustment · reference category for the HRs not stated | ||
| Death adjusted HR | 1.77 [95% CI: 1.65-1.91] | 1.81 [95% CI: 1.51-2.17] |
| AS-related hospitalization aHR | 2.27 [95% CI: 2.13-2.41] | 2.40 [95% CI: 2.08-2.77] |
- Death and AS-related hospitalization: death: P = 0.81
- Death and AS-related hospitalization: AS-related hospitalization: P = 0.42
Characteristics of symptomatic vs asymptomatic patients
- Mean age, symptomatic vs not
- 78 vs 75 years; P < 0.01
- Female, symptomatic vs not
- 51% vs 47%; P < 0.01
- Greater comorbidity burden in symptomatic patients
Death and AS-related hospitalization · median follow-up of 2.2 years
- Symptom status strongly predicted risk
Original publication
The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality. JACC Adv. Published 21 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →