The differential impact of abdominal obesity on fasting and non-fasting triglycerides and cardiovascular risk
Authors' conclusion
Polygenic score for abdominal obesity has a stronger effect on non-fasting than fasting TG levels, reflecting impaired postprandial lipid metabolism.
Study context
- Population
- UK Biobank participants with random TG levels and self-reported fasting duration
- Participants
- 352,782 participants
- Outcome
- Interaction of abdominal obesity (WHRadjBMI phenotype and polygenic score) with fasting duration on TG levels, and implications for CVD risk (MI and stroke incidence)
Methodological detailsUK Biobank, polygenic score
- UK Biobank
- Polygenic score
Main finding
As reported in the abstract
Effect of WHRadjBMI on TG levels modified by fasting duration
- Interaction with fasting duration, waist-hip ratio adjusted for BMI (WHRadjBMI) phenotype
- PInteraction= 6.5x10-32
- Interaction with fasting duration, WHRadjBMI polygenic score
- PInteraction=0.034
- Polygenic score increased non-fasting TG more than fasting TG per SD increase in WHRadjBMI
- 0.1 mmol/L
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) risk by TG levels
- Higher TG levels, regardless of fasting status, associated with higher CVD risk
Association of WHRadjBMI polygenic score with CVD risk, adjusted for TG
- Attenuation after adjusting for non-fasting TG (HR=1.41 to HR=1.30)
- 27%
- Attenuation after adjusting for fasting TG (HR=1.38 to HR=1.34)
- 11%
Original publication
The differential impact of abdominal obesity on fasting and non-fasting triglycerides and cardiovascular risk. Eur J Prev Cardiol. Published 17 February 2025. doi:10.
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