Timing of Complete Multivessel Revascularization in Patients Presenting With Non-ST-Segment Elevation Acute Coronary Syndrome
Authors' conclusion
ICR is safe in patients with NSTE-ACS and MVD and was associated with a reduction in MIs and UIDRs at 1 year.
Study context
- Population
- Patients with NSTE-ACS and multivessel diseaseNSTE-ACS of 1,525 enrolled
- Participants
- 917 patients
- Comparison
- Immediate vs staged complete revascularization
- Immediate complete revascularization (ICR)n = 459
- Staged complete revascularization (SCR)n = 458reference
- Primary endpoint
- Composite of:
- All-cause mortality
- Myocardial infarction (MI)
- Unplanned ischemia-driven revascularization
- Cerebrovascular events
- Follow-up
- 1 year
Methodological detailsprespecified substudy
- Prespecified substudy
Primary result
As reported in the abstract
Composite of:
- All-cause mortality
- MI
- Unplanned ischemia-driven revascularization (UIDR)
- Cerebrovascular events
- Incidences of the primary composite outcome similar in the 2 groups
Further findings
| Outcome | ICR | SCR | Risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| MI · 1 year | 2.0% | 5.3% | 3.3% (0.9–5.7) | P = 0.006 | |
| MI excluding procedure-related MIs · 1 year | 2.0% | 4.4% | 2.4% (0.1–4.7) | P = 0.032 | |
| Unplanned ischemia-driven revascularization · 1 year | 4.2% | 7.8% | 3.5% (0.4–6.6) | P = 0.018 | |
| −50510Difference (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Timing of Complete Multivessel Revascularization in Patients Presenting With Non-ST-Segment Elevation Acute Coronary Syndrome. JACC Cardiovasc Interv. Published 25 March 2024. doi:10.
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