Prognostic value of combined coronary CT angiography and myocardial perfusion imaging in women and men
Authors' conclusion
Among patients evaluated for chronic chest pain, women have a lower prevalence of ischaemic CAD and a lower rate of adverse events. Combined coronary CTA and PET myocardial perfusion imaging predict outcomes equally in women and men.
Study context
- Population
- Patients with suspected coronary artery disease (CAD) referred for coronary computed tomography angiography (CTA), 2008–2016; those with suspected obstructive lesion underwent 15O-water positron emission tomography (PET) stress myocardial blood flow (MBF)59% women
- Participants
- 1,948 patients
- Exposure
- Women vs men
- Outcome
- Adverse events:
- All-cause death
- MI
- Unstable angina
- Follow-up
- Mean 6.8 years
Main finding
As reported in the abstract
Annual adverse event rate
P = 0.02
Observational data: associations, not effects.
Further findings
Normal coronary arteries
P < 0.001
Abnormal stress MBF
P < 0.001
| Outcome | Women | Men |
|---|---|---|
| Predictors of adverse events | ||
| Fold adverse event rate with abnormal stress MBF | 5.0 | 5.6 |
- Abnormal stress MBF: PET performed in 657 with suspected obstructive lesion
Predictors of adverse events
- Coronary calcification, non-obstructive CAD and abnormal stress MBF independent predictors of events in both sexes
- No interaction between sex and coronary calcification, non-obstructive CAD or abnormal stress MBF for predicting adverse events
Original publication
Prognostic value of combined coronary CT angiography and myocardial perfusion imaging in women and men. Eur Heart J Cardiovasc Imaging. Published 22 April 2023. doi:10.
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