Valvular & structural heart disease
The Pulmonary Artery Pulsatility Index in Patients with Severe Aortic Stenosis Undergoing Valve Replacement
Authors' conclusion
In unselected patients with severe AS, the PAPi did not predict post-AVR mortality.
Study context
- Population
- Unselected patients with severe aortic stenosis (AS) undergoing right heart catheterization before aortic valve replacement (AVR)74 ± 10 years, 58% males
- Participants
- 487 patients
- Exposure
- Pulmonary artery pulsatility index (PAPi) quartiles
- Outcome
- Post-AVR mortality
- Follow-up
- Median 45 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Post-AVR mortality across PAPi quartiles · median 45 months
Mortality did not differ across PAPi quartiles, independent of AVR mode
log rank P = 0.50
Observational data: associations, not effects.
Further findings
PAPi components and mortality
- Higher pulmonary artery pulse pressure (PAPP), lower pulmonary artery capacitance (PAC), lower stroke volume index (SVI) and higher mean right atrial pressure (mRAP) associated with increased mortality
Characteristics of lowest PAPi quartile
- Similar AS severity, symptoms, BNP and surgical risk vs higher quartiles
- Lowest PAPP, highest mRAP, slightly reduced SVI, highest PAC
PAPi, whole cohort
- Mean PAPi
- 4.7 ± 3.3
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Pulmonary Artery Pulsatility Index in Patients with Severe Aortic Stenosis Undergoing Valve Replacement. ESC Heart Fail. Published 17 July 2025. doi:10.
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