Heart failure & cardiomyopathies
The relationship of diuretics and dietary sodium in patients with heart failure: an analysis of the SODIUM-HF trial
Authors' conclusion
Although a higher baseline diuretic dose was associated with worse clinical outcomes, no association was found between dietary sodium restriction, baseline or change in diuretic dose and the primary outcomes.
Study context
- Population
- Patients with HF in the SODIUM-HF trial784 with known diuretic status
- Participants
- 806 patients
- Comparison
- Dietary sodium restriction vs usual care, by furosemide-equivalent diuretic dose
- 0mgn = 209
- 1mg to 39mgn = 134
- 40mgn = 205
- 41mg to 80mgn = 118
- > 80mgn = 118
- Primary endpoint
- CV-related ED visit, CV-related hospitalization and all-cause mortality
- Follow-up
- 2-year
Primary result
As reported in the abstract
- Risk of primary outcomes strongly correlated with baseline diuretic dose
- P < 0.001
- No significant association between treatment arm and risk of primary outcomes, within each baseline dose range or with change in dose
- P > 0.05
Further findings
Correlation of dietary sodium intake with diuretic dose
- No correlation at baseline or with change throughout the study
- P > 0.05
Original publication
The relationship of diuretics and dietary sodium in patients with heart failure: an analysis of the SODIUM-HF trial. Am Heart J. Published 4 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →