Valvular & structural heart disease
The role of cardiovascular magnetic resonance (CMR) in the timing of aortic valve interventions and risk stratification in aortic regurgitation: a systematic review and meta-analysis
Pooled result · Clinic outcomes with an ARF > 33%Result — go to the resultPooled hazard ratio 4.12 95% CI 2.31–7.34Authors' conclusion
CMR-derived ARF is strongly predictive of clinical outcomes. ARF > 33% is associated with significantly increased risk, warranting its integration into clinical decision-making frameworks.
Study context
- Population
- Patients with aortic regurgitation assessed with CMR-derived aortic regurgitation (AR) fraction (AR fraction (ARF))Eight studies included in the meta-analysis (12 met inclusion criteria, 1235 screened)
- Participants
- 1,996 patients
- Comparison
- CMR-derived ARF > 33% and clinic outcomes
- Outcome
- Clinic outcomes with an ARF > 33%
- Follow-up
- Ranged from 2 to 5.1 years
Methodological detailsrandom-effects model, observational studies
- Random-effects model
- Observational studies
Pooled result
As reported in the abstract
Pooled hazard ratio
4.12
95% CI 2.31–7.34
P < 0.01
ARF > 33%
pooled HR 4.12 (95% CI 2.31–7.34); P < 0.01
- Highest reported HR
- 24.59
- Lowest reported HR
- 1.04
Further pooled results
ARF severity thresholds
- Range
- 30 to 43%
- Mean
- 33.7%
Original publication
The role of CMR in the timing of aortic valve interventions and risk stratification in aortic regurgitation: a systematic review and meta-analysis. Eur Heart J Cardiovasc Imaging. Published 9 December 2025. doi:10.
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