Valvular & structural heart disease
Cardiac Remodeling Following Transcatheter Tricuspid Valve Annuloplasty for Tricuspid Regurgitation: A Real-World, Multicenter Analysis
Authors' conclusion
TTVA is associated with a significant and sustained reduction of TR for more than 1 year. Additionally, patients demonstrated distinct positive cardiac remodeling and functional improvement.
Study context
- Population
- Consecutive patients undergoing transcatheter tricuspid valve annuloplasty (TTVA) (Cardioband) for severe tricuspid regurgitation (TR), 2019–2023
- Participants
- 156 patients
- Exposure
- Follow-up vs baseline after TTVA
- Outcome
- Long-term efficacy and right heart remodeling (right atrial and RV parameters, NYHA class)
- Follow-up
- Median 435 days
Methodological detailsmulticentre, 2 German high-volume centres
- Multicentre
- 2 German high-volume centres
Main finding
As reported in the abstract
| Group | Right atrial area | Right ventricular (RV) length | RV midventricular dimension | RV basal dimension |
|---|---|---|---|---|
| Baseline | 36.0 ± 10.1 cm² | 67.5 ± 9.4 mm | 42.6 ± 8.6 mm | 47.8 ± 6.8 mm |
| Follow-up | 30.4 ± 10.7 cm² | 63.7 ± 9.1 mm | 35.6 ± 7.8 mm | 42.6 ± 7.5 mm |
Right atrial area
Baseline36.0 ± 10.1 cm²
Follow-up30.4 ± 10.7 cm²
Right ventricular (RV) length
Baseline67.5 ± 9.4 mm
Follow-up63.7 ± 9.1 mm
RV midventricular dimension
Baseline42.6 ± 8.6 mm
Follow-up35.6 ± 7.8 mm
RV basal dimension
Baseline47.8 ± 6.8 mm
Follow-up42.6 ± 7.5 mm
- TR reduction to ≤2+
- 71%
- NYHA class improved to ≤II
- 68%
- TR and NYHA improvement
- P < 0.001
- All right heart dimensions significantly reduced at follow-up
- P < 0.001
Observational data: associations, not effects.
Further findings
Association of right heart remodeling with decrease in vena contracta width
| OR (95% CI) | P value | ||
|---|---|---|---|
| Decrease in vena contracta width | 1.14 (1.03–1.30) | P = 0.015 | |
| 0.512Odds ratio (log scale) |
RV basal diameter, torrential to severe TR reduction (subgroup)
- RV basal diameter baseline vs follow-up
- 50 ± 8.1 mm vs 44 ± 8 mm; P = 0.007
Original publication
Cardiac Remodeling Following Transcatheter Tricuspid Valve Annuloplasty for Tricuspid Regurgitation: A Real-World, Multicenter Analysis. JACC Cardiovasc Interv. Published 8 December 2025. doi:10.
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