Heart failure & cardiomyopathies
The Water Imbalance of Skeletal Muscle and Muscle Weakness in Patients with Heart Failure
Authors' conclusion
A high ECW/ICW ratio in limb muscles, that is, the water imbalance of increasing ECW and/or decreasing ICW, is useful in assessing muscle quality in patients with HF.
Study context
- Population
- Patients with heart failure (HF)
- Participants
- 190 patients
- Exposure
- High vs low extracellular water (ECW)/intracellular water (ICW) ratio of limb skeletal muscle
- Outcome
- Handgrip strength
Methodological detailsBioelectrical impedance analysis of upper and lower extremities; low muscle strength by Asian Working Group for Sarcopenia handgrip criteria
- Bioelectrical impedance analysis of upper and lower extremities; low muscle strength by Asian Working Group for Sarcopenia handgrip criteria
Main finding
As reported in the abstract
P ≤ 0.05
- High ECW/ICW ratio and low skeletal muscle mass independently associated with low muscle strength (multivariate logistic regression)
- P < 0.05
- Increasing ECW and/or decreasing ICW associated with higher ECW/ICW ratio and lower handgrip strength
- P < 0.05
Observational data: associations, not effects.
Further findings
6-min walk distance
Original publication
The Water Imbalance of Skeletal Muscle and Muscle Weakness in Patients with Heart Failure. ESC Heart Fail. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →