Heart failure & cardiomyopathiesCohort study
Tissue characterization using cardiac magnetic resonance imaging and response to cardiac resynchronization therapy
- Retrospective cohort study
Authors' conclusion
Cardiac magnetic resonance-based tissue parameters effectively predict CRT response and clinical outcomes in patients with NICM, independently of conventional predictors.
Study context
- Population
- Patients with non-ischaemic cardiomyopathy (NICM) with cardiac magnetic resonance (CMR) before cardiac resynchronization therapy (CRT) implantation72 (71.3%) CRT responders
- Participants
- 101 patients
- Exposure
- CRT responders vs CRT non-responders
- CRT respondersn = 72
- Outcome
- CRT response (prognostic value of CMR tissue characterization: Late gadolinium enhancement (LGE), native T1, T2, extracellular volume (ECV))
Main finding
As reported in the abstract
CMR parameters, responders vs non-responders
LGE burden
P < 0.001
ECV
P < 0.001
ms
| Outcome | CRT responders | CRT non-responders | P value |
|---|---|---|---|
| Native T1 | 1334.5 | 1371.6 | P = 0.012 |
| T2 | 42.2 | 45.7 | P < 0.001 |
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Adjusted predictors of good CRT response — LGE burden ≤ 20% vs CRT non-responders · adjusted | 22.61 (4.73–176.68) | P < 0.001 | |
| Adjusted predictors of good CRT response — ECV ≤ 34% vs CRT non-responders · adjusted | 15.93 (3.01–115.13) | P = 0.002 | |
| Adjusted predictors of good CRT response — T2 ≤ 45 ms vs CRT non-responders · adjusted | 8.10 (1.82–43.75) | P = 0.008 | |
| 0.050.21520Odds ratio (log scale) |
- Adjusted predictors of good CRT response — Favourable clinical outcomes with these parameters
- log-rank P < 0.001
Original publication
Tissue characterization using cardiac magnetic resonance imaging and response to cardiac resynchronization therapy. Europace. Published 10 April 2025. doi:10.1093/europace/euaf043
Summarised from the published abstract; every number is checked against it