Heart failure & cardiomyopathies
Long-Term Nonprogression Is a Form of Response to Cardiac Resynchronization Therapy
Main finding · Composite of all-cause death, implantation of a ventricular assist device, or heart transplantationResult — go to the resultAdjusted hazard ratio 2.26 95% CI 1.35–3.78Authors' conclusion
Nonprogressors form a relevant, to date poorly characterized group of CRT patients, whose long-term survival is significantly better compared to progressors or negative responders.
Study context
- Population
- Heart failure patients after cardiac resynchronization therapy (CRT) implantation23% female, mean age 65 years, mean baseline LVEF 27%
- Participants
- 391 patients
- Exposure
- Progressors compared to nonprogressors
- Nonprogressorsn = 134reference
- Outcome
- Composite of:
- All-cause death
- Implantation of a ventricular assist device
- Heart transplantation
- Follow-up
- Mean another 57 months
Main finding
As reported in the abstract
Adjusted hazard ratio
2.26
95% CI 1.35–3.78
P = 0.002
Progressorsvs nonprogressors
adjusted HR 2.26 (95% CI 1.35–3.78); P = 0.002
Observational data: associations, not effects.
Further findings
Timing of postimplantation echocardiography
- Postimplantation echocardiograms performed after a mean of
- 37 months
Original publication
Long-Term Nonprogression Is a Form of Response to Cardiac Resynchronization Therapy. JACC Adv. Published 26 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →