Traditional risk factors, optimal cardiovascular health, and elevated lipoprotein(a)
Authors' conclusion
Participants without clinical ASCVD who achieved an optimal LS7 score had ASCVD risk reduction regardless of Lp(a) level.
Study context
- Population
- Participants without clinical atherosclerotic cardiovascular disease (ASCVD) from MESA who underwent Lp(a) testing
- Participants
- 6,676 participants
- Exposure
- Optimal vs poor LS7 score across Lp levels
- Outcome
- Incident ASCVD (CHD and stroke)
- Follow-up
- Median 17.7 years
Methodological detailssecondary analysis of the Multi-Ethnic Study of Atherosclerosis
- Secondary analysis of the Multi-Ethnic Study of Atherosclerosis
Main finding
As reported in the abstract
Incident ASCVD, optimal vs poor LS7, by Lp(a) level
Optimal LS7 vs Poor LS7Hazard ratio (95% CI)
Lp(a) < 30 mg/dL
0.45(0.28–0.71)
Lp(a) 30-49 mg/dL
0.12(0.02–0.89)
Lp(a) ≥ 50 mg/dL
0.35(0.13–0.99)
- No significant interaction between Lp(a) and LS7 score on incident ASCVD
- P for interaction = 0.60
Observational data: associations, not effects.
Original publication
Traditional risk factors, optimal cardiovascular health, and elevated lipoprotein(a). Eur J Prev Cardiol. Published 28 November 2024. doi:10.
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