Heart failure & cardiomyopathies
Training-Induced Change of Diastolic Function in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
In patients with HFpEF, exercise echocardiography revealed increases in filling pressures as well as a failure to augment right ventricular function during exercise. After 3 months of exercise training, HFpEF patients demonstrated a small improvement in diastolic function (exercise E/e′), but this did not explain the improved aerobic capacity.
Study context
- Population
- Patients with heart failure and preserved ejection fraction (HFpEF)included in substudy, parent trial randomized 180 patients
- Participants
- 61 patients
- Comparison
- Patients of both training groups were pooled and compared with guideline control
Methodological detailsrandomized 1:1:1, exercise echocardiography at baseline and 3 months, two out of five participating sites, training groups pooled
- Randomized 1:1:1
- Exercise echocardiography at baseline and 3 months
- Two out of five participating sites
- Training groups pooled
Primary result
As reported in the abstract
- E/e′ increased from 17.0 ± 5.7 to 19.5 ± 6.1
- P < 0.001
Further findings
| Outcome | Training | Control | P value |
|---|---|---|---|
| V̇O2peak change · 3 months | +2.7 mL/kg/min | +0.2 mL/kg/min | P = 0.006 |
| Exercise E/e′ · 3 monthsSmall but significant improvements | 18.3 ± 5.0 to 17.2 ± 4.1 | 21.7 ± 7.5 to 22.8 ± 9.2 | P = 0.044 |
Systolic pulmonary artery pressure during exercise at baseline
- Increased from 31 ± 8 to 51 ± 11 mmHg
- P < 0.001
Right ventricular function (maximal tricuspid annular plane systolic excursion) · baseline
- Maximal tricuspid annular plane systolic excursion 24.7 ± 4.0 mm, did not change significantly
- P = 0.051 vs. baseline
Ejection fraction, mitral or tricuspid annular plane systolic excursion, S′, A′, systolic pulmonary artery pressure · 3 months
- No significant changes
- P > 0.05
Association of change in E/e′ with change in V̇O2peak
- Changes in E/e′ were not associated with the change in V̇O2peak
Baseline characteristics
- Mean age
- 73 ± 7 years
- Female
- 72%
Original publication
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