Valvular & structural heart disease
Transcatheter Aortic Valve Replacement for Pure Native Aortic Valve Regurgitation: The PANTHEON International Project
Authors' conclusion
Despite improved THV platforms and techniques, TAVR for pure severe NAVR remains a challenging procedure, with significant risk for TVEM. SE and BE platforms demonstrated comparable performance in this setting.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) with currently available devices for pure severe native aortic valve regurgitation (NAVR)
- Participants
- 201 patients
- Exposure
- SE vs BE new-generation transcatheter heart valves (THVs) for TAVR
- Outcome
- Technical and device success; composite of all-cause mortality and HF rehospitalization
- Follow-up
- 1 year (composite)
Main finding
As reported in the abstract
Overall technical success
83.6%
Overall device success
76.1%
Observational data: associations, not effects.
Further findings
Residual moderate or greater aortic regurgitation
P = 0.87
| Outcome | P value |
|---|---|
| Composite of all-cause mortality and HF rehospitalization, TVEM vs no TVEM · 1 year | P = 0.05 |
- Composite of all-cause mortality and HF rehospitalization, TVEM vs no TVEM: TVEM 25.7%
- Composite of all-cause mortality and HF rehospitalization, TVEM vs no TVEM: No TVEM 15.8%
Safety
Acute transcatheter valve embolization or migration (TVEM)
P = 0.47
Original publication
Transcatheter Aortic Valve Replacement for Pure Native Aortic Valve Regurgitation: The PANTHEON International Project. JACC Cardiovasc Interv. Published 28 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →