Valvular & structural heart disease
Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy
Primary result · Death, stroke or rehospitalization, patients with tricuspid ASResult — go to the resultAbsolute risk difference −2.0% 95% CI −11.8% to 7.7%Authors' conclusion
These analyses are exploratory, but highlight the importance of tailoring the intervention to the patient's clinical risk profile, life expectancy, native aortic valve morphology and the anticipated risks associated with TAVR or SAVR.
Study context
- Population
- Low surgical risk patients aged ≤ 70 years with a tricuspid or bicuspid aortic valve stenosis (AS)
- Comparison
- Transcatheter aortic valve replacement (TAVR) when compared to surgical aortic valve replacement (SAVR)
Methodological detailsexploratory analyses
- Exploratory analyses
Primary result
As reported in the abstract
Death, stroke or rehospitalization, patients with tricuspid AS · One year after intervention
Absolute risk difference
−2.0%
95% CI −11.8% to 7.7%
TAVRvs SAVR
absolute risk difference −2.0% (95% CI −11.8% to 7.7%)
Further findings
| Outcome | Absolute risk difference (95% CI) | |
|---|---|---|
| Adverse outcomes (death, stroke or rehospitalization), patients with bicuspid AS · One year after interventionSignificantly higher risk with TAVR · exploratory | 13.8% (1.2%–26.3%) | |
| −2002040Difference (linear scale) |
Original publication
Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy. Am Heart J. Published 12 February 2025. doi:10.
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