Valvular & structural heart disease
Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials
Pooled result · All-cause deathResult — go to the resultHazard ratio 0.80 95% CI 0.66–0.97Authors' conclusion
In lower-risk patients, TAVR was associated with a reduced hazard of death and death or disabling stroke compared with SAVR, while rates of stroke were equivalent.
Study context
- Population
- Lower-risk patients with severe AS
- Participants
- 5,341 patients · 6 RCTs
- Comparison
- Transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR)
- TAVRn = 2,717
- SAVRn = 2,624reference
- Outcome
- All-cause death
- Follow-up
- 5 years
Methodological detailsreconstructed time-to-event individual participant data (IPD), pooled survival analyses, Weighted mean follow-up 35.7 months
- Reconstructed time-to-event IPD
- Pooled survival analyses
- Weighted mean follow-up 35.7 months
Pooled result
All-cause death
Hazard ratio
0.80
95% CI 0.66–0.97
P = 0.02
TAVR vs SAVR
HR 0.80 (95% CI 0.66–0.97); P = 0.02
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause death or disabling stroke · 5 years · 19% reduction in hazard · pooled survival analyses of reconstructed time-to-event IPD | 0.81 (0.68–0.96) | P = 0.01 | |
| 0.512Hazard ratio (log scale) |
Stroke
- No difference in stroke (HR: 0.97; 95% CI: 0.74-1.26)
- P = 0.80
Original publication
Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Coll Cardiol. Published 11 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it