Arrhythmias & electrophysiology
Translational approach to ventricular innervation: the posterior descending ganglionated plexus
Authors' conclusion
The present translational approach to ventricular innervation demonstrates first evidence of the functional relevance of the PDGP, with morphological findings indicating species-related differences.
Study context
- Population
- Ex vivo retrograde-perfused porcine hearts; C57BL/6 mice; explanted human heartsmurine studies n = 43
- Comparison
- Functional posterior descending GP (PDGP) modulation vs paced rhythm
- Outcome
- Role of the posterior descending GP (PDGP) for neural control of cardiac electrophysiology
Methodological detailsproof-of-principle, systematic literature review, murine morphological studies, ex vivo retrograde-perfused porcine model, explanted human hearts
- Proof-of-principle
- Systematic literature review
- Murine morphological studies
- Ex vivo retrograde-perfused porcine model
- Explanted human hearts
Main finding
As reported in the abstract
Dispersion of conduction velocity
High-frequency stimulation vs Paced rhythm: P = 0.018 · Nicotine stimulation vs Paced rhythm: P = 0.044
Further findings
Activation recovery intervals with high-frequency stimulation, RV regions vs posterior LV — Posterior RV vs Posterior LV
P = 0.044
| Outcome | P value |
|---|---|
| Activation recovery intervals with high-frequency stimulation, RV regions vs posterior LVBasal RV vs Posterior LV | P = 0.039 |
Ventricular ganglionated plexus (GPs) in murine hearts
- Ventricular GPs present in only 10% of hearts (n = 43)
Human hearts
- PDGP present in epicardial adipose tissue near its eponymous coronary artery and the posteromedial left atrial GP
- 3D reconstruction suggested PDGP localization with inter-patient anatomical variability
Original publication
Translational approach to ventricular innervation: the posterior descending ganglionated plexus. Europace. Published 13 May 2025. doi:10.
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