Heart failure & cardiomyopathies
Treatment Response in Recent-Onset Heart Failure with Reduced Ejection Fraction: Non-Ischaemic vs. Ischaemic Aetiology
Authors' conclusion
In recent-onset HFrEF, patients with non-IHF responded better to GDMT than patients with IHF.
Study context
- Population
- Patients hospitalised with recent-onset HFrEF (left ventricular ejection fraction (LVEF) < 40%) starting guideline-directed medical treatment (GDMT), 2016–201947 not investigated for ischaemic heart disease (IHD)
- Participants
- 364 patients
- Exposure
- Non-ischaemic vs ischaemic aetiology of recent-onset HFrEF
- non-IHFn = 203reference
- IHFn = 114
- Outcome
- Hierarchical clinical composite outcome (worsened, improved or unchanged) based on mortality, heart transplantation, heart failure (HF) hospitalisation, LVEF, NT-proBNP and NYHA class changes
- Follow-up
- 28 weeks
Main finding
As reported in the abstract
non-IHF
- Worsened
- 19.1%
- Improved
- 74.2%
IHF
- Worsened
- 43.9%
- Improved
- 43.9%
Worsened
non-IHF19.1%
IHF43.9%
Improved
non-IHF74.2%
IHF43.9%
IHF vs non-IHFOdds ratio (95% CI)P value
Worsening; multivariable-adjusted
2.94(1.51–5.74)
P = 0.002Improvement; multivariable-adjusted
0.35(0.18–0.65)
P < 0.001Observational data: associations, not effects.
Further findings
Decision for coronary investigation (no previous IHD or new-onset MI)
- Coronary investigation decided (n = 261)
- 69.0%
Original publication
Treatment Response in Recent-Onset Heart Failure with Reduced Ejection Fraction: Non-Ischaemic vs. Ischaemic Aetiology. ESC Heart Fail. Published 4 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →