Pulmonary vascular disease & thromboembolism
Trends in catheter-directed therapy and in-hospital outcomes among patients with acute pulmonary embolism: insights from a multicentre national quality assurance database registry
Authors' conclusion
In a national quality assurance database of patients with PE included in the PERT registry, the use of catheter-directed treatment increased over time. Compared with a nationwide NIS sample, these patients had lower in-hospital mortality and shorter hospital length of stay.
Study context
- Population
- Patients with acute pulmonary embolism enrolled in the PERT™ Consortium registry, years 2018–2024enrolled at 51 sites, 10,883 matched to the Nationwide Inpatient Sample (NIS) population
- Participants
- 11,436 patients
- Exposure
- PERT™ Consortium registry patients vs matched NIS population
- PERT™ Consortium registryn = 10,883
- Outcome
- Use of catheter-directed treatment (CDT)
Methodological detailsnational quality assurance database, age-, sex-, and PE risk-matched comparison with US Nationwide Inpatient Sample (NIS)
- National quality assurance database
- Age-, sex-, and PE risk-matched comparison with US Nationwide Inpatient Sample (NIS)
Main finding
As reported in the abstract
PERT™ Consortium registry
23.1%
2639
- Of those who underwent catheter-directed treatment (CDT): catheter-directed thrombolysis without ultrasound
- 140 (5.3%)
- Of those who underwent CDT: ultrasound-assisted catheter thrombolysis
- 851 (32.2%)
- Of those who underwent CDT: mechanical thrombectomy/aspiration
- 1534 (58.1%)
Observational data: associations, not effects.
Further findings
| Outcome | Difference (CI) | |
|---|---|---|
| Matched comparison with NIS: CDT use, in-hospital mortality, length of stayPERT™ Consortium registryvs NIS | 1.3% (0.6–2.0%) | |
| −10123Difference (linear scale) |
| Outcome | Difference (days) (CI) | |
|---|---|---|
| Matched comparison with NIS: CDT use, in-hospital mortality, length of stayPERT™ Consortium registryvs NIS | 0.75 (0.2–1.3) | |
| −1012Difference, days (linear scale) |
- Matched comparison with NIS: CDT use, in-hospital mortality, length of stay — Standardized mean difference in CDT use, PERT™ Consortium registry vs NIS (95% CI, 21-23%)
- 22%
- Matched comparison with NIS: CDT use, in-hospital mortality, length of stay: in-hospital mortality; lower among PERT™ Consortium registry patients
- Matched comparison with NIS: CDT use, in-hospital mortality, length of stay: hospital stay; fewer days among PERT™ Consortium registry patients
Other advanced treatments (of all patients)
- Systemic thrombolysis
- 5.6%
- Surgical embolectomy
- 1.1%
- ECMO
- 1.6%
Trends over time (quarterly, linear regression)
- CDT
- +0.36% quarterly; P = 0.002
- Mechanical thrombectomy
- +0.83%; P < 0.001
- Catheter-directed thrombolysis
- −0.4%; P = 0.001
Original publication
Trends in catheter-directed therapy and in-hospital outcomes among patients with acute pulmonary embolism: insights from a multicentre national quality assurance database registry. Eur Heart J Acute Cardiovasc Care. Published 23 December 2025. doi:10.
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