Valvular & structural heart disease
Trends, Predictors, and Outcomes of Bleeding Complications After Mitral Transcatheter Edge-to-Edge Repair: TVT Registry Insights
Main finding · Death or readmissionResult — go to the resultAdjusted odds ratio 2.15 95% CI 1.81–2.54Authors' conclusion
Bleeding after M-TEER is associated with increased risk of subsequent death and hospital readmission.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) in the TVT Registry, 2013–2022
- Participants
- 51,533 patients
- Exposure
- In-hospital major or life-threatening bleeding vs no bleeding after M-TEER
- Bleedingn = 1,205
- Outcome
- Composite of:
- Death
- Hospital readmission
- Follow-up
- 30 days
Methodological detailsregistry-based (TVT Registry)
- Registry-based (TVT Registry)
Main finding
Death or readmission
Adjusted odds ratio
2.15
95% CI 1.81–2.54
P < 0.0001
Bleedingvs No bleeding
adjusted OR 2.15 (95% CI 1.81–2.54); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Death or readmission · 1 year | 1.43 (1.27–1.60) | P < 0.0001 | |
| 0.512Adjusted hazard ratio (log scale) |
In-hospital major bleeding incidence
- Overall incidence
- 1,205 (2.3%)
- Decrease over time, 2013 to 2021
- 7.1% to 2.0%; P < 0.001
Predictors of in-hospital bleeding
- Strongest correlates: female sex, prior PCI, baseline hemoglobin, greater procedure acuity, longer procedure duration
Original publication
Trends, Predictors, and Outcomes of Bleeding Complications After Mitral Transcatheter Edge-to-Edge Repair: TVT Registry Insights. JACC Cardiovasc Interv. Published 28 October 2024. doi:10.
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