Heart failure & cardiomyopathies
The Utility of Urine Biomarkers in Diuretic Resistance Prediction in Heart Failure Hospitalization
Authors' conclusion
Urine pi-GST concentration may serve as a marker for the development of LDR in patients with HF hospitalization.
Study context
- Population
- Patients hospitalised for congestive HF
- Participants
- 40 patients
- Outcome
- Loop diuretic resistance (persistent congestion despite high IV loop diuretic doses)
- Follow-up
- Fourth day of hospitalization
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Prediction of LDR
| Group | AUC | Sensitivity | Specificity |
|---|---|---|---|
| Urine pi-GST | 0.713 (95% CI 0.552-0.874; P = 0.009) | 50% | 84% |
Urine pi-GST
AUC0.713 (95% CI 0.552-0.874; P = 0.009)
Sensitivity50%
Specificity84%
- Loop diuretic resistance (LDR) incidence
- 14 (35%)
Observational data: associations, not effects.
Further findings
Univariate risk factors for LDR
- Urine pi-GST concentration on admission and on the fourth day, TAPSE/PASP ratio, serum creatinine and total cholesterol concentrations
Multivariable analysis for LDR
- Only urine pi-GST was a significant independent risk factor for LDR
Original publication
The Utility of Urine Biomarkers in Diuretic Resistance Prediction in Heart Failure Hospitalization. ESC Heart Fail. Published 29 October 2025. doi:10.
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