Valvular & structural heart disease
Contemporary Insights Into the Epidemiology, Impact and Treatment of Secondary Tricuspid Regurgitation Across the Heart Failure Spectrum
Authors' conclusion
Secondary tricuspid regurgitation is frequent, increasing with age and associated with excess mortality independent of HF subtype. Nevertheless, sTR is rarely treated surgically or percutaneously.
Study context
- Population
- Patients with heart failure (HF) and secondary tricuspid regurgitation (sTR) from the Viennese community over a 10-year period
- Participants
- 13,469 patients
- Exposure
- Moderate or severe sTR vs no/mild sTR in HF
- Severe sTRn = 1,514
- Outcome
- Long-term mortality
Main finding
As reported in the abstract
Each group vs No/mild sTRHazard ratio (95% CI)P value
Moderate sTR
1.58(1.48–1.69)
P < 0.001Severe sTR
2.19(2.01–2.38)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR for death (95% CI) | P value | |
|---|---|---|---|
| Mortality vs expected survival of sex- and age-matched communityModerate sTRvs Sex- and age-matched community (expected survival) | 6.32 (5.88–6.80) | P < 0.001 | |
| Mortality vs expected survival of sex- and age-matched communitySevere sTRvs Sex- and age-matched community (expected survival) | 9.04 (8.27–9.87) | P < 0.001 | |
| 0.10.31310HR for death (log scale) |
Mortality vs expected survival of sex- and age-matched community
- Excess mortality independent of HF subtype
Severe sTR mortality, by age (subgroup)
- Severe sTR mortality risk more pronounced in younger patients (<70 years)
Treatment of moderate and severe sTR
- Moderate and severe sTR rarely treated
- 3%, n = 147
Original publication
Contemporary Insights Into the Epidemiology, Impact and Treatment of Secondary Tricuspid Regurgitation Across the Heart Failure Spectrum. Eur J Heart Fail. Published 1 May 2023. doi:10.
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