Arrhythmias & electrophysiology
Two-year outcomes of left bundle branch area pacing versus traditional right ventricular pacing in middle-aged adults: a registry-based trial
Primary result · CV death or HFHResult — go to the resultHazard ratio 0.78 95% CI 0.59–0.87Authors' conclusion
Left bundle branch area pacing significantly lowered the 2-year composite of CV death and HFH compared to RVP in patients aged <65 years old. However, it did not reduce CV or all-cause mortality individually compared to RVP.
Study context
- Population
- Patients younger than 65 years requiring pacing (TREEBEARD registry)
- Participants
- 344 participants
- Comparison
- Left bundle branch area pacing (LBBAP) vs right ventricular pacing (RVP)
- LBBAPn = 172
- RVPn = 172reference
- Primary endpoint
- Composite of:
- CV death
- Heart failure (HF) hospitalization
- Follow-up
- 2 years
Methodological detailsregistry-based, 1:1 randomisation
- Registry-based
- 1:1 randomisation
Primary result
CV death or HF hospitalization (HFH)
Hazard ratio
0.78
95% CI 0.59–0.87
By group
LBBAP vs RVP
HR 0.78 (95% CI 0.59–0.87)
As reported in the abstract
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| HF hospitalization | 0.79 (0.63–0.86) | |
| CV mortality | 1.02 (0.79–1.32) | |
| All-cause mortality | 1.00 (0.72–1.38) | |
| 0.512Hazard ratio (log scale) |
Primary endpoint, subgroups
- Subgroup analyses aligned with primary findings
Original publication
Two-year outcomes of left bundle branch area pacing versus traditional right ventricular pacing in middle-aged adults: a registry-based trial. Europace. Published 29 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →